منابع مشابه
Mitochondrial genomes: anything goes.
Mitochondria have their own genetic system – a vestigial genome originating from an endosymbiotic a-proteobacterial ancestor. The genetic function of mitochondrial DNA (mtDNA) is well-conserved, being involved in a maximum of five mitochondrial processes: invariantly in respiration and/or oxidative phosphorylation and translation, and also in transcription, RNA maturation and protein import. Re...
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earlier studies reported the existence of E1 and E2 enzymes within mitochondria (Magnani et al, 1991; Schwartz et al, 1992). In addition, a more recent and growing body of evidence shows that mitochondria also contain specific E3 ligases with a prominent role in the regulation of mitochondrial dynamics. In particular, Mitol/ March5—a ubiquitin E3 ligase embedded in the outer membrane— participa...
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The brain iron overload disorders, collectively known as neurodegeneration with brain iron accumulation (NBIA), would seem to be tantalizing targets for chelation therapy. Efforts to lower brain iron in these disorders date back to the 1960s with deferoxamine mesylate, but systemic iron depletion limited its use. With the advent of chelators better able to specifically relieve central nervous s...
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chicken chemokine can help heal wounds by inducing fibroblasts to become myofibroblasts, according to results reported by Feugate et al. on page 161. The contractile myofibroblasts help close the wound by pulling together the necessary cells and matrix. Chemokines are better known for their activities in the immune system, but increased production of chicken chemotactic and angiogenic factor (c...
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Motivated by recent developments in solid electrolytes based on lithium phosphorous oxynitride (LiPON) materials, we carried out computer simulations in order to develop an understanding of the detailed mechanisms of ionic transport. Starting with crystalline Li3PO4, we investigated some possible structures of isolated defects associated with extrinsic Li ion vacancies and interstitials. In par...
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ژورنال
عنوان ژورنال: Genes & Development
سال: 2013
ISSN: 0890-9369
DOI: 10.1101/gad.219451.113